Lucia OLARIU, Mihaela PETCU, Stela CUNA, Camelia TULCAN, Corina GRAVILA,
Snejana PETROVICI, Mihaela PUP, Ileana BRUDIU
Abstract. The deuterium depleted water has a special influence on cells and tissues development. A decreasing of the deuterium concentration in tissues or bodies, significant slow down the proliferation of a lot of types of cancer. The aim of this work was to determine the antioxidant effect of deuterium depleted water (DDW) on rats with chromium induced oxidative damages (20 ppm Cr/ b.w. single dose as K2Cr2O7). Deuterium, malondialdehyde (MDA) and glutathione (GSH) blood levels were determined. After Cr(VI) intoxication, increased MDA and low GSH levels were registered. DDW administration could maintain both small deuterium and normal MDA and GSH levels. Low levels of deuterium in cells are favorable for good cell function. DDW performed an important Cr (VI) scavenger role in the rats`liver.
Key words: deuterium depleted water, malondialdehyde, glutathione, chromium, blood, rats