HEPATOPROTECTIVE AND GASTRO PROTECTIVE STUDIES OF Terminalia arjuna LEAVES EXTRACT AND PHYTOCHEMICAL PROFILE

Ataa SAID1, Ahlam M. El-FISHAWY2, Siham El-SHENAWY3, Usama W. HAWAS4, Mohamed ABOELMAGD1

DOI: 10.7904/2068–4738–V(10)–30

1Pharmacognosy Department, National Research Center, Dokki, Giza, EGYPT. 2Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza, EGYPT. 3Pharmacology Department, National Research Center, Dokki, Giza, EGYPT. 4Phytochemistry and Plant Systematic Department, National Research Center, Dokki, Giza, EGYPT; e–mail: m.magd83@yahoo.com

Abstract. The methanol extract of T. arjuna leaves was evaluated as hepatoprotective and gastroprotective against Swiss albino rats. In hepatoprotective study the liver damage induced by paracetamol while the gastric lesion induced by absolute ethanol in the gastro protective study. The extract was given orally (250,500 and 1000 mg/kg) in different experimental models in both studies. The extract at dose (500mg/kg) showed significant reduction in ALT serum level by 19.9% while at dose (1000mg/kg) it reduced significantly serum ALT, AST and ALP levels by –26.15,–25.46 and –23.69 % respectively as compared with paracetamol treated group. In the gastro protective study the extract produced significant reduction in the number and severity of mucosal lesion by (–52.1 &–67.3 %, –66.7 &–71.2 % and –68.8 &–77.6%) respectively.

Key words: T. arjuna, hepatoprotective, gastroprotective, mucosal lesion

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