Changes in elemental composition of Lewis carcinoma tumors in mice due to the supply of water–ethanolic extracts of Artemisia dracunculus and Pastinaca sativa

DOI: 10.7904/2068-4738-XI(22)-11

 

Nadezhda Golubkina1*, Kirill Kirsanov2, Valentina Deryagina2, Nataly Rizhova2, Ludmila Savluchinskaya2, Irina Golubeva2, Gianluca Caruso3

 1 Laboratory Analytical Department, Federal Scientific Center of Vegetable Production, Odintsovo district, 143072 Moscow region, Russia.

2 Laboratory of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow 115478, Russia.

Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici (Naples), Italy.

* Corresponding author, e–mail: segolubkina45@gmail.com, tel: +7–903–118–50–30 (N.G.).

 

Abstract. Macro– and trace elements play an important role in biological processes, connected with malignant tumors emergence and development. Despite numerous data on elemental composition of tumour tissues up to date, the effect of plant preparations on elemental composition of tumors has been poorly investigated. In order to evaluate the elemental composition of mice Lewis carcinoma tumors under Artemisia dracunculus (tarragon) and Pastinaca sativa (‘black parsnip’) ethanolic extracts ingestion and to characterize mineral content in the above herbs, ICP–MS– method was used. The results demonstrated significant decrease of Сd, Pb, Hg, Al, Mn, Sr and Se concentrations in Lewis carcinoma tumors of mice under tarragon and ‘black parsnip’ ethanolic extracts loading compared to control group of mice without supply of herbs extracts. ‘Black parsnip’ and tarragon extracts also increased the concentrations of Ca, Si and V in tumors. Contrary to tarragon extract, which increased I content in tumors, ‘Black parsnip” significantly decreased the accumulation of I. Taking into account the anti–carcinogenic and anti–metastatic effects of ‘black parsnip’ and the pro–carcinogenic effect of A. dracunculus, their utilization in preventive medicine is supposed to arise interesting prospects.

Keyword: Lewis carcinoma; tarragon; ‘black parsnip’; plant extracts; elemental composition; iodine.

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