Alina BUTU, Mariana FERDES, Steliana RODINO, Marian BUTU
Abstract: Humans, animals and plants are constantly subject to pathogen microorganisms attack. The biggest threat to organisms is represented by fungal attack. Permanently seeking for new solutions to prevent and treatment of diseases caused by fungi, the researchers have turned their attention to antimicrobial peptides. These are produced by a large variety of organisms. The plans are the most important source of peptides having antifungal properties. In the present article is revealed a study of the molecular dynamics of such a peptide, namely the antimicrobial peptide WAMP–1a. Since the conformational structure of the peptide sequence is directly related to its activity, the dynamic parameters were analysed and were identified the amino acid residues that show the largest flexibility.
Keywords: plant antimicrobial peptide, molecular dynamics simulation, “in silico” methods, fungal diseases.